The_Yan_Report
Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of Its Probable Synthetic Route

“31. Has SARS-CoV-2been subjected to in vitromanipulation?We present three lines ofevidence to support our contention that laboratory manipulation is part of the history of SARS-CoV-2:
i.The genomic sequence of SARS-CoV-2 is suspiciously similarto that of a bat coronavirus discovered by military laboratoriesin the Third Military Medical University (Chongqing, China) and the Research Institute for Medicine of Nanjing Command (Nanjing, China).

ii.The receptor-binding motif (RBM) within the Spike protein of SARS-CoV-2, which determines the host specificityof the virus,resembles that of SARS-CoV from the 2003 epidemic in a suspicious manner. Genomic evidence suggests that the RBM has been genetically manipulated.

iii.SARS-CoV-2 contains a unique furin-cleavage sitein its Spike protein,which is known to greatly enhance viral infectivity and cell tropism. Yet, this cleavage siteis completely absent in this particular class of coronavirusesfound in nature.In addition, rare codons associated with this additional sequence suggest the strong possibilitythat thisfurin-cleavage site is not the product of natural evolution and couldhave beeninsertedinto the SARS-CoV-2 genomeartificiallyby techniques other than simple serial passage or multi-strain recombination events inside co-infected tissue cultures oranimals.”